TIBC

TIBC (Total Iron-Binding Capacity) represents the maximum amount of iron required to fully saturate iron-carrying proteins, namely Transferrin.
In other words, TIBC is the sum of UIBC (Unsaturated Iron-Binding Capacity) and Iron,
which indicates the sites that can be bound to Iron in the serum as well as the serum Iron.
Its use is in the diagnosis of various types of anemia and is often increased in times of Iron deficiency in the body
and decreases in chronic disorders, malignancies and hemochromatosis.
TIBC (Total Iron-Binding Capacity) represents the maximum amount of iron required to fully saturate iron-carrying proteins, namely Transferrin.
In other words, TIBC is the sum of UIBC (Unsaturated Iron-Binding Capacity) and Iron,
which indicates the sites that can be bound to Iron in the serum as well as the serum Iron.
Its use is in the diagnosis of various types of anemia and is often increased in times of Iron deficiency in the body
and decreases in chronic disorders, malignancies and hemochromatosis.

Iron

IRON is an essential factor in the formation of hemoglobin in red blood cells, which is found bound to Transferrin for transport in plasma or stored in Ferritin.
Increased iron levels are seen in hemochromatosis and liver damage.
Iron deficiency occurs in various types of anemia (due to incomplete absorption of iron due to digestive diseases)
Chronic bleeding (due to peptic ulcers), acute bleeding and heavy bleeding during menstruation.
To correctly determine the status of IRON in the body, measuring Transferrin (which is an iron-carrying protein)
and Ferritin (which has been proven to be a useful indicator of body iron stores) and TIBC (which is a measure of saturated
and unsaturated Transferrin and increases with decreasing IRON store values) can provide more details.

Ferritin

Ferritin is a compound of ferric hydroxide and the protein apoferritin and is a marker of iron storage, consisting of 24 units.
This complex is in the form of a hollow sphere that can accommodate 4000 iron atoms.
Ferritin is loaded with iron, the primary source of iron storage in cells and tissues, which is readily available for the synthesis of hemoglobin.
The most common form of stored iron is in the form of trivalent iron bound to ferritin.
Changes in serum ferritin levels are usually associated with changes in tissue ferritin concentration,
and measurement of serum ferritin concentration is actually a quantitative assessment of iron storage.
Therefore, a decrease in ferritin concentration is an indication of tissue iron depletion,
and its measurement is used to rapidly diagnose iron deficiency anemia.
Increased serum ferritin concentration can indicate iron overload associated with iron storage deficiencies (such as hereditary or acquired hemochromatosis).
This increase is also seen in the evaluation of clinical conditions unrelated to iron storage, such as chronic liver disease, infections, inflammation, and malignant tumors.